Endocrine Abstracts

Introduction: Pituitary ACTH-dependent Cushing’s syndrome (CS) is a condition characterized by an overproduction of cortisol due to pituitary adenoma which infers high morbidity and mortality. Transsphenoidal surgery (TSS) is the first-line therapy of an ACTH-secreting pituitary adenoma. But, even after surgical resection of the adenoma, up to 50% of cases may develop a recurrence of the disease.Case presentation: A woman, 32 year-old, developed rec...

Introduction: Familial hypocalciuric hypercalcaemia (FHH) is an autosomal dominant disorder affecting the calcium-sensing receptor (CaSR) expressed in the chief cells of the parathyroid glands and in the renal tubules. The CaSR permits the parathyroid gland to sense variations in serum calcium thus regulating parathyroid hormone (PTH) secretion; it also regulates calcium excretion in the kidneys. In FHH, loss-of-function mutations in the CaSR result in a higher serum calcium d...

Introduction: Adrenal myelolipomas are rare benign tumours consisting of fat and haematopoietic elements. We present an adult male patient with congenital adrenal hyperplasia (CAH) with an incidental diagnosis of bilateral adrenal myelolipomas, resulting in an improvement in adherence to treatment, but uncertainty regarding his future management.Case history: 53 year old man with known CAH was referred into the endocrine clinic, historically requiring la...

Background: The incidence of Paediatric type 2 diabetes is increasing, especially in areas of deprivation.Aim: To describe the cohort of CYP with T2D in Royal London Hospital over the period 2009–2018.Methods: Retrospective analysis of patient cohort.Results: Number of new patients doubled from 2.6/year in 2009–2013 to 5.3/year in 2014–2018. Prevalence in our cohort is 7.5% (national average of...

Case history: A 28-year-old gentleman was referred with symptoms of memory fog, difficulty with concentration, mood disturbance and fatigue. His thyroid function tests had been stable but abnormal for over 8 years, with a normal FT4 between 17–19 pmol/l (12–22 pmol/l), FT3 5.6 pmol/l (3.1–6.8 pmol/l) and an elevated TSH between 12–16 mu/l (0.27–4.2 mu/l). He had no family history of thyroid disease. He was clinically euthyroid. His weight had remained ...

: Lymphoma is one of the rare causes of bilateral adrenal gland enlargement that require a high index of suspicion for diagnosis. We present a case of 80-year-old lady referred by her GP for further evaluation after presenting with lower abdominal discomfort and weight loss for which she had a CT scan that revealed bilateral adrenal gland masses (60 HU) with the right adrenal gland measures 61 mm in diameter with distal ileal thickness and regional lymphadenopathy. She has no ...

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Introduction: Proteinuria is a condition in which urine contains an abnormal amount of protein. Proteinuria is a sign of chronic kidney disease (CKD), which can result from diabetes, high blood pressure and other diseases that cause inflammation in the kidneys. If CKD progresses, it can lead to end-stage renal disease, when the kidneys fail completely.Case presentation: Sixty-three years old female patient attended our clinic as her glycaemia was poor co...

Purpose: To investigate the carbohydrate metabolism in depend on acromegaly treatment.Material and methods: 23 patients with newly diagnosed acromegaly (NA) were observed. Carbohydrate metabolism were investigated after somatostatine analogues treatment (SSA) (14 patients) or after surgery (TSA) (9 patients). Groups were comparable on age, BMI, acromegaly duration. Were researched HbA1c, fasting plasma glucose level (FPG), indexes of insulin resistance (...

In recent years, the integrated clinical academic pathway has made a previously seemingly chaotic career pathway far more organised. This is now a well-trodden path; for those interested in research, there are opportunities to join this pathway at every stage, from academic foundation programmes through to fellowships aimed at those post-CCT. Combining clinical training in endocrinology (and not forgetting diabetes and general internal medicine too) with research, whether basi...